Quantitative Prediction of OATP‐Mediated Drug‐Drug Interactions With Model‐Based Analysis of Endogenous Biomarker Kinetics

Quantitative prediction of the magnitude of transporter‐mediated clinical drug‐drug interactions (DDIs) solely from in vitro inhibition data remains challenging. The objective of the present work was to analyze the kinetic profile of an endogenous biomarker for organic anion‐transporting polypeptide...

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Detalles Bibliográficos
Autores principales: Yoshida, Kenta, Guo, Cen, Sane, Rucha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118294/
https://www.ncbi.nlm.nih.gov/pubmed/29924471
http://dx.doi.org/10.1002/psp4.12315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118294/
https://www.ncbi.nlm.nih.gov/pubmed/29924471
http://dx.doi.org/10.1002/psp4.12315

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