Neural stem cells from a mouse model of Rett syndrome are prone to senescence, show reduced capacity to cope with genotoxic stress, and are impaired in the differentiation process

Several aspects of stem cell life are governed by epigenetic variations, such as DNA methylation, histone modifications, and chromatin remodeling. Epigenetic events are also connected with the impairment of stem cell functions. For example, during senescence, there are significant changes in chromat...

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Detalles Bibliográficos
Autores principales: Alessio, Nicola, Riccitiello, Francesco, Squillaro, Tiziana, Capasso, Stefania, Del Gaudio, Stefania, Di Bernardo, Giovanni, Cipollaro, Marilena, Melone, Mariarosa A. B., Peluso, Gianfranco, Galderisi, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118406/
https://www.ncbi.nlm.nih.gov/pubmed/29563495
http://dx.doi.org/10.1038/s12276-017-0005-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118406/
https://www.ncbi.nlm.nih.gov/pubmed/29563495
http://dx.doi.org/10.1038/s12276-017-0005-x

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