Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression

Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying mechanisms driving hematopoietic stem cell loss remain unknown. Using a mouse model of SAA, we demonstrate that IFNγ-dependent h...

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Detalles Bibliográficos
Autores principales: McCabe, Amanda, Smith, Julianne N.P., Costello, Angelica, Maloney, Jackson, Katikaneni, Divya, MacNamara, Katherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119154/
https://www.ncbi.nlm.nih.gov/pubmed/29773597
http://dx.doi.org/10.3324/haematol.2018.189449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119154/
https://www.ncbi.nlm.nih.gov/pubmed/29773597
http://dx.doi.org/10.3324/haematol.2018.189449

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