Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

OBJECTIVES: We sought to understand why randomised controlled trials in septic shock have failed to demonstrate effectiveness in the face of improving overall outcomes for patients and seemingly promising results of early phase trials of interventions. DESIGN: We performed a retrospective analysis o...

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Detalles Bibliográficos
Autores principales: Wong, Joshua L C, Mason, Alexina J, Gordon, Anthony C, Brett, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Intensive Care
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119416/
https://www.ncbi.nlm.nih.gov/pubmed/30158216
http://dx.doi.org/10.1136/bmjopen-2017-020068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119416/
https://www.ncbi.nlm.nih.gov/pubmed/30158216
http://dx.doi.org/10.1136/bmjopen-2017-020068

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