IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells

Activation of the high-affinity receptor for IgE (FcεRI) follows a bell-shaped dose-response curve. Upon supra-optimal stimulation, mast cell effector responses are down-regulated by inhibitory molecules like the SH2-containing inositol-5′-phosphatase SHIP1 and the SRC-family-kinase LYN. To identify...

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Detalles Bibliográficos
Autores principales: Gast, Mathias, Preisinger, Christian, Nimmerjahn, Falk, Huber, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119721/
https://www.ncbi.nlm.nih.gov/pubmed/30210494
http://dx.doi.org/10.3389/fimmu.2018.01937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119721/
https://www.ncbi.nlm.nih.gov/pubmed/30210494
http://dx.doi.org/10.3389/fimmu.2018.01937

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