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Cell surface expression of homomeric GABA(A) receptors depends on single residues in subunit transmembrane domains

Cell surface expression of type A GABA receptors (GABA(A)Rs) is a critical determinant of the efficacy of inhibitory neurotransmission. Pentameric GABA(A)Rs are assembled from a large pool of subunits according to precise co-assembly rules that limit the extent of receptor structural diversity. Thes...

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Detalles Bibliográficos
Autores principales: Hannan, Saad, Smart, Trevor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120189/
https://www.ncbi.nlm.nih.gov/pubmed/29986886
http://dx.doi.org/10.1074/jbc.RA118.002792