Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3

Mixed-lineage kinase 3 (MLK3; also known as MAP3K11) is a Ser/Thr protein kinase widely expressed in normal and cancerous tissues, including brain, lung, liver, heart, and skeletal muscle tissues. Its Src homology 3 (SH3) domain has been implicated in MLK3 autoinhibition and interactions with other...

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Detalles Bibliográficos
Autores principales: Kokoszka, Malgorzata E., Kall, Stefanie L., Khosla, Sehar, McGinnis, Jennifer E., Lavie, Arnon, Kay, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120190/
https://www.ncbi.nlm.nih.gov/pubmed/29980598
http://dx.doi.org/10.1074/jbc.RA117.000262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120190/
https://www.ncbi.nlm.nih.gov/pubmed/29980598
http://dx.doi.org/10.1074/jbc.RA117.000262

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