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Off‐target inhibition by active site‐targeting SHP2 inhibitors

Due to the involvement of SHP2 (SH2 domain‐containing protein‐tyrosine phosphatase) in human disease, including Noonan syndrome and cancer, several inhibitors targeting SHP2 have been developed. Here, we report that the commonly used SHP2 inhibitor NSC‐87877 does not exhibit robust inhibitory effect...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Ryouhei, Ran, Hao, Neel, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120237/
https://www.ncbi.nlm.nih.gov/pubmed/30186742
http://dx.doi.org/10.1002/2211-5463.12493