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In Situ Cyclization of Native Proteins: Structure‐Based Design of a Bicyclic Enzyme
Increased tolerance of enzymes towards thermal and chemical stress is required for many applications and can be achieved by macrocyclization of the enzyme resulting in the stabilizing of its tertiary structure. Thus far, macrocyclization approaches utilize a very limited structural diversity, which...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120448/ https://www.ncbi.nlm.nih.gov/pubmed/29847004 http://dx.doi.org/10.1002/anie.201804506 |