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Impaired fear extinction in serotonin transporter knockout rats is associated with increased 5‐hydroxymethylcytosine in the amygdala

AIMS: One potential risk factor for posttraumatic stress disorder (PTSD) involves the low activity (short; s) allelic variant of the serotonin transporter‐linked polymorphic region (5‐HTTLPR), possibly due to reduced prefrontal control over the amygdala. Evidence shows that DNA methylation/demethyla...

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Detalles Bibliográficos
Autores principales: Shan, Ling, Guo, Hang‐Yuan, van den Heuvel, Corina N. A. M., van Heerikhuize, Joop, Homberg, Judith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120487/
https://www.ncbi.nlm.nih.gov/pubmed/29427306
http://dx.doi.org/10.1111/cns.12822