Inheritance of OCT4 predetermines fate choice in human embryonic stem cells

It is well known that clonal cells can make different fate decisions, but it is unclear whether these decisions are determined during, or before, a cell's own lifetime. Here, we engineered an endogenous fluorescent reporter for the pluripotency factor OCT4 to study the timing of differentiation...

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Detalles Bibliográficos
Autores principales: Wolff, Samuel C, Kedziora, Katarzyna M, Dumitru, Raluca, Dungee, Cierra D, Zikry, Tarek M, Beltran, Adriana S, Haggerty, Rachel A, Cheng, JrGang, Redick, Margaret A, Purvis, Jeremy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120590/
https://www.ncbi.nlm.nih.gov/pubmed/30177503
http://dx.doi.org/10.15252/msb.20178140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120590/
https://www.ncbi.nlm.nih.gov/pubmed/30177503
http://dx.doi.org/10.15252/msb.20178140

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