Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis

Somatic mutations show variation in density across cancer genomes. Previous studies have shown that chromatin organization and replication time domains are correlated with, and thus predictive of, this variation. Here, we analyze 1809 whole-genome sequences from 10 cancer types to show that a subset...

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Detalles Bibliográficos
Autores principales: Georgakopoulos-Soares, Ilias, Morganella, Sandro, Jain, Naman, Hemberg, Martin, Nik-Zainal, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120622/
https://www.ncbi.nlm.nih.gov/pubmed/30104284
http://dx.doi.org/10.1101/gr.231688.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120622/
https://www.ncbi.nlm.nih.gov/pubmed/30104284
http://dx.doi.org/10.1101/gr.231688.117

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