Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest

The initiation of apoptosis in response to the disruption of mitosis provides surveillance against chromosome instability. Here, we show that proteolytic destruction of the key regulator Mcl‐1 during an extended mitosis requires the anaphase‐promoting complex or cyclosome (APC/C) and is independent...

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Detalles Bibliográficos
Autores principales: Allan, Lindsey A, Skowyra, Agnieszka, Rogers, Katie I, Zeller, Désirée, Clarke, Paul R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120658/
https://www.ncbi.nlm.nih.gov/pubmed/29987118
http://dx.doi.org/10.15252/embj.201796831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120658/
https://www.ncbi.nlm.nih.gov/pubmed/29987118
http://dx.doi.org/10.15252/embj.201796831

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