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Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest
The initiation of apoptosis in response to the disruption of mitosis provides surveillance against chromosome instability. Here, we show that proteolytic destruction of the key regulator Mcl‐1 during an extended mitosis requires the anaphase‐promoting complex or cyclosome (APC/C) and is independent...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120658/ https://www.ncbi.nlm.nih.gov/pubmed/29987118 http://dx.doi.org/10.15252/embj.201796831 |