Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

RIPK2 mediates inflammatory signaling by the bacteria‐sensing receptors NOD1 and NOD2. Kinase inhibitors targeting RIPK2 are a proposed strategy to ameliorate NOD‐mediated pathologies. Here, we reveal that RIPK2 kinase activity is dispensable for NOD2 inflammatory signaling and show that RIPK2 inhib...

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Detalles Bibliográficos
Autores principales: Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120666/
https://www.ncbi.nlm.nih.gov/pubmed/30026309
http://dx.doi.org/10.15252/embj.201899372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120666/
https://www.ncbi.nlm.nih.gov/pubmed/30026309
http://dx.doi.org/10.15252/embj.201899372

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