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Inhibition gates supralinear Ca(2+) signaling in Purkinje cell dendrites during practiced movements

Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction with parallel fiber activity, a pairing that enhanc...

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Detalles Bibliográficos
Autores principales: Gaffield, Michael A, Rowan, Matthew J M, Amat, Samantha B, Hirai, Hirokazu, Christie, Jason M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120752/
https://www.ncbi.nlm.nih.gov/pubmed/30117806
http://dx.doi.org/10.7554/eLife.36246