Cargando…
Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells
Prostate cancer (PCa), a leading cause of cancer-related death in men, becomes resistant to androgen deprivation therapy by inducing androgen receptor (AR) activity, which is known as castration-resistant PCa (CRPC). Enzalutamide is an approved drug that inhibits AR activity and increases overall su...
Autores principales: | de las Pozas, Alicia, Reiner, Teresita, De Cesare, Virginia, Trost, Matthias, Perez-Stable, Carlos |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120934/ https://www.ncbi.nlm.nih.gov/pubmed/30177856 http://dx.doi.org/10.1038/s41598-018-31567-3 |
Ejemplares similares
-
Betulinic Acid Selectively Increases Protein Degradation and Enhances Prostate Cancer-Specific Apoptosis: Possible Role for Inhibition of Deubiquitinase Activity
por: Reiner, Teresita, et al.
Publicado: (2013) -
ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells
por: Parrondo, Ricardo, et al.
Publicado: (2013) -
NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells
por: Parrondo, Ricardo, et al.
Publicado: (2010) -
Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage
por: Reiner, Teresita, et al.
Publicado: (2015) -
Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity
por: Huguenin-Dezot, Nicolas, et al.
Publicado: (2016)