6 Hz Active Anticonvulsant Fluorinated N-Benzamide Enaminones and Their Inhibitory Neuronal Activity

A small library of novel fluorinated N-benzamide enaminones were synthesized and evaluated in a battery of acute preclinical seizure models. Three compounds (GSA 62, TTA 35, and WWB 67) were found to have good anticonvulsant activity in the 6-Hz ‘psychomotor’ 44-mA rodent model. The focus of this st...

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Detalles Bibliográficos
Autores principales: Amaye, Isis J., Heinbockel, Thomas, Woods, Julia, Wang, Zejun, Martin-Caraballo, Miguel, Jackson-Ayotunde, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121254/
https://www.ncbi.nlm.nih.gov/pubmed/30127263
http://dx.doi.org/10.3390/ijerph15081784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121254/
https://www.ncbi.nlm.nih.gov/pubmed/30127263
http://dx.doi.org/10.3390/ijerph15081784

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