A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both Status Epilepticus and Optic Nerve Crush Animal Models

Recently, we showed that matrix metalloproteinase-12 (MMP-12) is highly expressed in microglia and myeloid infiltrates, which are presumably involved in blood–brain barrier (BBB) leakage and subsequent neuronal cell death that follows status epilepticus (SE). Here, we assessed the effects of a hydro...

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Detalles Bibliográficos
Autores principales: Vinet, Jonathan, Costa, Anna-Maria, Salinas-Navarro, Manuel, Leo, Giuseppina, Moons, Lieve, Arckens, Lutgarde, Biagini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121268/
https://www.ncbi.nlm.nih.gov/pubmed/30044455
http://dx.doi.org/10.3390/ijms19082178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121268/
https://www.ncbi.nlm.nih.gov/pubmed/30044455
http://dx.doi.org/10.3390/ijms19082178

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