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The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice

Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have prov...

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Autores principales: Estrada-Reyes, Rosa, Valdés-Tovar, Marcela, Arrieta-Baez, Daniel, Dorantes-Barrón, Ana María, Quero-Chávez, Daniel, Solís-Chagoyán, Héctor, Argueta, Jesús, Dubocovich, Margarita L., Benítez-King, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121277/
https://www.ncbi.nlm.nih.gov/pubmed/30081472
http://dx.doi.org/10.3390/ijms19082278
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author Estrada-Reyes, Rosa
Valdés-Tovar, Marcela
Arrieta-Baez, Daniel
Dorantes-Barrón, Ana María
Quero-Chávez, Daniel
Solís-Chagoyán, Héctor
Argueta, Jesús
Dubocovich, Margarita L.
Benítez-King, Gloria
author_facet Estrada-Reyes, Rosa
Valdés-Tovar, Marcela
Arrieta-Baez, Daniel
Dorantes-Barrón, Ana María
Quero-Chávez, Daniel
Solís-Chagoyán, Héctor
Argueta, Jesús
Dubocovich, Margarita L.
Benítez-King, Gloria
author_sort Estrada-Reyes, Rosa
collection PubMed
description Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have proved effectiveness as antidepressants in clinical trials. However, there is contradictory evidence about the potential antidepressant effect of melatonin itself. Herein we studied melatonin administration in mice at two zeitgeber times (ZT; ZT = 0 lights on; 12:12 L/D), one hour before the beginning (ZT11) and at the middle (ZT18) of the dark phase after either a single or a three-dose protocol. Behavioral despair was assessed through a forced-swimming test (FST) or a tail suspension test (TST), at ZT18.5. A single dose of 4 mg/kg melatonin at ZT11 was effective to reduce the immobility time in both tests. However, acute administration of melatonin at ZT18 was not effective in mice subjected to FST, and a higher dose (16 mg/kg) was required to reduce immobility time in the TST. A three-dose administration protocol of 16 mg/kg melatonin (ZT18, ZT11, and ZT18) significantly reduced immobility time in FST. Data indicate that the timely administration of melatonin could improve its antidepressant-like effect.
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spelling pubmed-61212772018-09-07 The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice Estrada-Reyes, Rosa Valdés-Tovar, Marcela Arrieta-Baez, Daniel Dorantes-Barrón, Ana María Quero-Chávez, Daniel Solís-Chagoyán, Héctor Argueta, Jesús Dubocovich, Margarita L. Benítez-King, Gloria Int J Mol Sci Article Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have proved effectiveness as antidepressants in clinical trials. However, there is contradictory evidence about the potential antidepressant effect of melatonin itself. Herein we studied melatonin administration in mice at two zeitgeber times (ZT; ZT = 0 lights on; 12:12 L/D), one hour before the beginning (ZT11) and at the middle (ZT18) of the dark phase after either a single or a three-dose protocol. Behavioral despair was assessed through a forced-swimming test (FST) or a tail suspension test (TST), at ZT18.5. A single dose of 4 mg/kg melatonin at ZT11 was effective to reduce the immobility time in both tests. However, acute administration of melatonin at ZT18 was not effective in mice subjected to FST, and a higher dose (16 mg/kg) was required to reduce immobility time in the TST. A three-dose administration protocol of 16 mg/kg melatonin (ZT18, ZT11, and ZT18) significantly reduced immobility time in FST. Data indicate that the timely administration of melatonin could improve its antidepressant-like effect. MDPI 2018-08-03 /pmc/articles/PMC6121277/ /pubmed/30081472 http://dx.doi.org/10.3390/ijms19082278 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Estrada-Reyes, Rosa
Valdés-Tovar, Marcela
Arrieta-Baez, Daniel
Dorantes-Barrón, Ana María
Quero-Chávez, Daniel
Solís-Chagoyán, Héctor
Argueta, Jesús
Dubocovich, Margarita L.
Benítez-King, Gloria
The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice
title The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice
title_full The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice
title_fullStr The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice
title_full_unstemmed The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice
title_short The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice
title_sort timing of melatonin administration is crucial for its antidepressant-like effect in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121277/
https://www.ncbi.nlm.nih.gov/pubmed/30081472
http://dx.doi.org/10.3390/ijms19082278
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