PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis

PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a transcriptional coactivator of many genes involved in energy management and mitochondrial biogenesis. PGC-1α expression is associated with cellular senescence, organismal aging, and many age-related diseases, includin...

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Detalles Bibliográficos
Autores principales: Kaarniranta, Kai, Kajdanek, Jakub, Morawiec, Jan, Pawlowska, Elzbieta, Blasiak, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121367/
https://www.ncbi.nlm.nih.gov/pubmed/30087287
http://dx.doi.org/10.3390/ijms19082317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121367/
https://www.ncbi.nlm.nih.gov/pubmed/30087287
http://dx.doi.org/10.3390/ijms19082317

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