Role of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors

Tyrosine kinase inhibitors are a rapidly expanding class of molecular targeted therapies for the treatment of various types of cancer and other diseases. An increasing number of clinically important small molecule tyrosine kinase inhibitors have been shown to undergo cytochrome P450-mediated bioacti...

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Detalles Bibliográficos
Autores principales: Jackson, Klarissa D., Durandis, Rebecca, Vergne, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121577/
https://www.ncbi.nlm.nih.gov/pubmed/30103502
http://dx.doi.org/10.3390/ijms19082367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121577/
https://www.ncbi.nlm.nih.gov/pubmed/30103502
http://dx.doi.org/10.3390/ijms19082367

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