Cargando…

Role of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors

Tyrosine kinase inhibitors are a rapidly expanding class of molecular targeted therapies for the treatment of various types of cancer and other diseases. An increasing number of clinically important small molecule tyrosine kinase inhibitors have been shown to undergo cytochrome P450-mediated bioacti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jackson, Klarissa D., Durandis, Rebecca, Vergne, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121577/ https://www.ncbi.nlm.nih.gov/pubmed/30103502 http://dx.doi.org/10.3390/ijms19082367

Ejemplares similares

Role of cytochrome P-450 and related enzymes in the pulmonary metabolism of xenobiotics.
por: Philpot, R M, et al.
Publicado: (1984)

Roles of Human Liver Cytochrome P450 Enzymes in Tenatoprazole Metabolism
por: Le, Thien-Kim, et al.
Publicado: (2022)

Cytochrome P450 Enzymes and Drug Metabolism in Humans
por: Zhao, Mingzhe, et al.
Publicado: (2021)

The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism
por: Haduch, Anna, et al.
Publicado: (2023)

Tyrosine Hydroxylation in Betalain Pigment Biosynthesis Is Performed by Cytochrome P450 Enzymes in Beets (Beta vulgaris)
por: Sunnadeniya, Rasika, et al.
Publicado: (2016)

Role of Cytochrome P450 Enzymes in Plant Stress Response
por: Pandian, Balaji Aravindhan, et al.
Publicado: (2020)

Enzyme Activity of Natural Products on Cytochrome P450
por: Zuo, Hua-Li, et al.
Publicado: (2022)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
por: Wang, Hao, et al.
Publicado: (2020)

Cytochrome P450 2C19 enzyme, Cytochrome P450 2C9 enzyme, and Cytochrome P450 2D6 enzyme allelic variants and its possible effect on drug metabolism: A retrospective study
por: Naujokaitis, Domas, et al.
Publicado: (2021)

Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines
por: Alfieri, Roberta R, et al.
Publicado: (2011)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Insights on Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies
por: Sridhar, Jayalakshmi, et al.
Publicado: (2012)

Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy
por: Preissner, Sarah C., et al.
Publicado: (2013)

An update on the role of intestinal cytochrome P450 enzymes in drug disposition
por: Xie, Fang, et al.
Publicado: (2016)

A history of the roles of cytochrome P450 enzymes in the toxicity of drugs
por: Guengerich, F. Peter
Publicado: (2020)

The Role of Cytochrome P450 Enzymes in COVID-19 Pathogenesis and Therapy
por: Wang, Guyi, et al.
Publicado: (2022)

Structure and function of the cytochrome P450 peroxygenase enzymes
por: Munro, Andrew W., et al.
Publicado: (2018)

Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes
por: Kumar, Santosh, et al.
Publicado: (2012)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

The Role of Cytochromes P450 in Infection
por: Stavropoulou, Elisavet, et al.
Publicado: (2018)

1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
por: de Montellano, Paul R Ortiz
Publicado: (2018)

The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
por: Reed, Lindsay, et al.
Publicado: (2018)

Degradation of Diuron by Phanerochaete chrysosporium: Role of Ligninolytic Enzymes and Cytochrome P450
por: Coelho-Moreira, Jaqueline da Silva, et al.
Publicado: (2013)

Streptomyces Cytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic Agents
por: Cho, Myung-A, et al.
Publicado: (2019)

An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes
por: Custodio, Joseph M., et al.
Publicado: (2020)

Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro
por: Ouyang, Dong-sheng, et al.
Publicado: (2016)

Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities
por: Hanapi, N. A., et al.
Publicado: (2013)

In vitro inhibitory effect of lysionotin on the activity of cytochrome P450 enzymes
por: Li, Yang, et al.
Publicado: (2020)

In vitro study on the effect of cornin on the activity of cytochrome P450 enzymes
por: Zhang, Qun, et al.
Publicado: (2021)

In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
por: Zhang, Cun, et al.
Publicado: (2021)

Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes
por: Ghosh, Sumit
Publicado: (2017)

Effect of citral on mouse hepatic cytochrome P450 enzymes
por: Tang, Huaqiao, et al.
Publicado: (2018)

Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway
por: Castaño, Patricia Rodríguez, et al.
Publicado: (2019)

Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea
por: Ngcobo, Phelelani Erick, et al.
Publicado: (2023)

Engineering of daidzein 3’-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450
por: Choi, Kwon-Young, et al.
Publicado: (2012)

The Central Role of Cytochrome P450 in Xenobiotic Metabolism—A Brief Review on a Fascinating Enzyme Family
por: Esteves, Francisco, et al.
Publicado: (2021)

Computational finding of potential inhibitor for Cytochrome P450 Mono-oxygenases Enzyme of Mycobacterium tuberculosis
por: Sharma, Ashwani, et al.
Publicado: (2012)

Role of Cytochrome P450 Enzyme in Plant Microorganisms’ Communication: A Focus on Grapevine
por: Minerdi, Daniela, et al.
Publicado: (2023)

Role of cytochrome P450 in drug interactions
por: Bibi, Zakia
Publicado: (2008)

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases
por: Illingworth, NA, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_0kaahi4drguuv3o78kd2f89dau