Protein Environment: A Crucial Triggering Factor in Josephin Domain Aggregation: The Role of 2,2,2-Trifluoroethanol

The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal Josephin domain and a disordered C-terminal tail wh...

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Detalles Bibliográficos
Autores principales: Visentin, Cristina, Navarro, Susanna, Grasso, Gianvito, Regonesi, Maria Elena, Deriu, Marco Agostino, Tortora, Paolo, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121581/
https://www.ncbi.nlm.nih.gov/pubmed/30042316
http://dx.doi.org/10.3390/ijms19082151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121581/
https://www.ncbi.nlm.nih.gov/pubmed/30042316
http://dx.doi.org/10.3390/ijms19082151

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