The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase

The mammalian DNA replication program is controlled at two phases, the licensing of potential origins of DNA replication in early gap 1 (G1), and the selective firing of a subset of licenced origins in the synthesis (S) phase. Upon entry into the S phase, serine/threonine-protein kinase ATR (ATR) is...

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Detalles Bibliográficos
Autores principales: Sokka, Miiko, Koalick, Dennis, Hemmerich, Peter, Syväoja, Juhani E., Pospiech, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121618/
https://www.ncbi.nlm.nih.gov/pubmed/30104465
http://dx.doi.org/10.3390/ijms19082376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121618/
https://www.ncbi.nlm.nih.gov/pubmed/30104465
http://dx.doi.org/10.3390/ijms19082376

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