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The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase
The mammalian DNA replication program is controlled at two phases, the licensing of potential origins of DNA replication in early gap 1 (G1), and the selective firing of a subset of licenced origins in the synthesis (S) phase. Upon entry into the S phase, serine/threonine-protein kinase ATR (ATR) is...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121618/ https://www.ncbi.nlm.nih.gov/pubmed/30104465 http://dx.doi.org/10.3390/ijms19082376 |