Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

BACKGROUND: The development of potent non-toxic chemotherapeutic drugs against castration resistant prostate cancer (CRPC) remains a major challenge. Corosolic acid (CA), a natural triterpenoid, has anti-cancer activity with limited side effects. However, CA anti-prostate cancer activities and mecha...

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Detalles Bibliográficos
Autores principales: Ma, Bo, Zhang, Hang, Wang, Yu, Zhao, Ang, Zhu, Zhiming, Bao, Xiaowen, Sun, Yang, Li, Lin, Zhang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122202/
https://www.ncbi.nlm.nih.gov/pubmed/30176898
http://dx.doi.org/10.1186/s13046-018-0889-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122202/
https://www.ncbi.nlm.nih.gov/pubmed/30176898
http://dx.doi.org/10.1186/s13046-018-0889-x

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