Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome

We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1....

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Autores principales: Alshaban, Ahmed, Padilla, Osvaldo, Philipovskiy, Alexander, Corral, Javier, McAlice, Meghan, Gaur, Sumit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122386/
https://www.ncbi.nlm.nih.gov/pubmed/30186759
http://dx.doi.org/10.1016/j.lrr.2018.08.001
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author Alshaban, Ahmed
Padilla, Osvaldo
Philipovskiy, Alexander
Corral, Javier
McAlice, Meghan
Gaur, Sumit
author_facet Alshaban, Ahmed
Padilla, Osvaldo
Philipovskiy, Alexander
Corral, Javier
McAlice, Meghan
Gaur, Sumit
author_sort Alshaban, Ahmed
collection PubMed
description We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1. Treatment with lenalidomide resulted in durable clinical remission which has lasted 2 years.
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spelling pubmed-61223862018-09-05 Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome Alshaban, Ahmed Padilla, Osvaldo Philipovskiy, Alexander Corral, Javier McAlice, Meghan Gaur, Sumit Leuk Res Rep Article We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1. Treatment with lenalidomide resulted in durable clinical remission which has lasted 2 years. Elsevier 2018-08-24 /pmc/articles/PMC6122386/ /pubmed/30186759 http://dx.doi.org/10.1016/j.lrr.2018.08.001 Text en © 2018 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Alshaban, Ahmed
Padilla, Osvaldo
Philipovskiy, Alexander
Corral, Javier
McAlice, Meghan
Gaur, Sumit
Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome
title Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome
title_full Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome
title_fullStr Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome
title_full_unstemmed Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome
title_short Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome
title_sort lenalidomide induced durable remission in a patient with mds/mpn-with ring sideroblasts and thrombocytosis with associated 5q- syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122386/
https://www.ncbi.nlm.nih.gov/pubmed/30186759
http://dx.doi.org/10.1016/j.lrr.2018.08.001
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