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Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage

BACKGROUND: Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, although some studies have indicated the involvement of endoplasmic reticulum stres...

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Detalles Bibliográficos
Autores principales: Wu, Yuping, Ma, Congshun, Zhao, Huihui, Zhou, Yuxia, Chen, Zhenguo, Wang, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122480/
https://www.ncbi.nlm.nih.gov/pubmed/30176887
http://dx.doi.org/10.1186/s12958-018-0404-4