Cargando…

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

BACKGROUND: The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Vincent, Chung, Liping, Singh, Amandeep, Lea, Vivienne, Abubakar, Askar, Lim, Stephanie H., Ng, Weng, Lee, Mark, de Souza, Paul, Shin, Joo-Shik, Lee, Cheok Soon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122630/ https://www.ncbi.nlm.nih.gov/pubmed/30176843 http://dx.doi.org/10.1186/s12885-018-4776-9

Ejemplares similares

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
por: Situ, Yiling, et al.
Publicado: (2019)

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells
por: McPherson, Matthew T., et al.
Publicado: (2020)

Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer
por: Brandt, Simone, et al.
Publicado: (2017)

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks
por: Lee, Joon, et al.
Publicado: (2013)

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
por: Lee, Ji-Hoon, et al.
Publicado: (2013)

Prognostic Significance of MRE11 Overexpression in Colorectal Cancer Patients
por: Ho, Vincent, et al.
Publicado: (2023)

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers
por: Ziółkowska-Suchanek, Iwona, et al.
Publicado: (2013)

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex
por: Otahalova, Barbora, et al.
Publicado: (2023)

Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival
por: Ho, Vincent, et al.
Publicado: (2017)

MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens
por: Kamisugi, Yasuko, et al.
Publicado: (2012)

Aberrant Expression of RAD52, Its Prognostic Impact in Rectal Cancer and Association with Poor Survival of Patients
por: Ho, Vincent, et al.
Publicado: (2020)

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex
por: Rahman, Samiur, et al.
Publicado: (2020)

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers
por: Alblihy, Adel, et al.
Publicado: (2021)

Deubiquitinase USP2 stabilizes the MRE11–RAD50–NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1
por: Kim, Hyunsup, et al.
Publicado: (2022)

Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma
por: Schuetz, Johanna M, et al.
Publicado: (2009)

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
por: Takeda, Shunichi, et al.
Publicado: (2016)

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
por: Bian, Lei, et al.
Publicado: (2019)

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency
por: Mariggiò, Giuseppe, et al.
Publicado: (2017)

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
por: Jazayeri, Ali, et al.
Publicado: (2008)

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
por: Spycher, Christoph, et al.
Publicado: (2008)

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis
por: Taylor, Elaine M., et al.
Publicado: (2010)

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1
por: Limbo, Oliver, et al.
Publicado: (2018)

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
por: Chang, Emily Yun-Chia, et al.
Publicado: (2019)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
por: Lee, Kyung Yong, et al.
Publicado: (2015)

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
por: Franchitto, Annapaola, et al.
Publicado: (2002)

Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
por: Belmonte-Fernández, Alejandro, et al.
Publicado: (2022)

Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel
por: Garner, Kristen M, et al.
Publicado: (2011)

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling
por: Henrich, Sarah Marie, et al.
Publicado: (2017)

NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle–dependent degradation of protein
por: Zhou, Hui, et al.
Publicado: (2017)

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
por: Sharma, Sheetal, et al.
Publicado: (2021)

MRE11 and ATM Expression Levels Predict Rectal Cancer Survival and Their Association with Radiotherapy Response
por: Ho, Vincent, et al.
Publicado: (2016)

Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity
por: Kim, Hyunsup, et al.
Publicado: (2021)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions
por: Hohl, Marcel, et al.
Publicado: (2011)

Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex
por: Vertemara, Jacopo, et al.
Publicado: (2023)

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links
por: Pasadi, Sanjeev, et al.
Publicado: (2020)

Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia
por: Mosor, Maria, et al.
Publicado: (2013)

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex
por: Chen, Yu-Jie, et al.
Publicado: (2016)

Somatic NGS Analysis of DNA Damage Response (DDR) Genes ATM, MRE11A, RAD50, NBN, and ATR in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemo-Radiotherapy
por: Montori, Andrea, et al.
Publicado: (2022)

Activation of the DNA-repair mechanism through NBS1 and MRE11 diffusion
por: Friis, Ida, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n1volt5cov436utiook194rh3t