DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer

BACKGROUND: Targeting TopoisomeraseII (TopoII) and generate enzyme mediated DNA damage is an effective strategy for treatment of breast cancer. TopoII is known as a validated target for drug discovery and cancer chemotherapy. METHODS: XWL-1-48, a new orally podophyllotoxin derivative, was designed a...

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Detalles Bibliográficos
Autores principales: Wang, Yajie, Sun, Hua, Xiao, Zhiyan, Zhang, Gang, Zhang, Dan, Bao, Xiuqi, Li, Fangfang, Wu, Shaoyu, Gao, Yuanchao, Wei, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122736/
https://www.ncbi.nlm.nih.gov/pubmed/30176902
http://dx.doi.org/10.1186/s12964-018-0263-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122736/
https://www.ncbi.nlm.nih.gov/pubmed/30176902
http://dx.doi.org/10.1186/s12964-018-0263-9

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