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Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene
BACKGROUND: In acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies have shown an anti-cancer effect of metformin. Therefore, the objective of this...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122769/ https://www.ncbi.nlm.nih.gov/pubmed/30176891 http://dx.doi.org/10.1186/s12967-018-1620-6 |