Macropinocytosis activated by oncogenic Dbl enables specific targeted delivery of Tat/pDNA nano-complexes into ovarian cancer cells

BACKGROUND: Successful implementation of gene therapy heavily relies on efficiently delivering genetic materials and specific targeting into cells. Oncogene-driven endocytosis stimulates nutrient uptake and also develops an endocytosis-mediated defense against therapeutic agents. Cell-penetrating pe...

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Detalles Bibliográficos
Autores principales: Niu, Xiuran, Gao, Zhihui, Qi, Shanshan, Su, Linjia, Yang, Nan, Luan, Xiuli, Li, Jia, Zhang, Qing, An, Yingli, Zhang, Sihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122892/
https://www.ncbi.nlm.nih.gov/pubmed/30214196
http://dx.doi.org/10.2147/IJN.S171361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122892/
https://www.ncbi.nlm.nih.gov/pubmed/30214196
http://dx.doi.org/10.2147/IJN.S171361

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