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Propofol inhibits prokaryotic voltage-gated Na(+) channels by promoting activation-coupled inactivation
Propofol is widely used in the clinic for the induction and maintenance of general anesthesia. As with most general anesthetics, however, our understanding of its mechanism of action remains incomplete. Local and general anesthetics largely inhibit voltage-gated Na(+) channels (Navs) by inducing an...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122921/ https://www.ncbi.nlm.nih.gov/pubmed/30018038 http://dx.doi.org/10.1085/jgp.201711924 |