All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner

Hyperpolarization-activated cyclic nucleotide–modulated (HCN) channels are tetramers that elicit electrical rhythmicity in specialized brain neurons and cardiomyocytes. The channels are dually activated by voltage and binding of cyclic adenosine monophosphate (cAMP) to their four cyclic nucleotide-b...

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Detalles Bibliográficos
Autores principales: Sunkara, Mallikarjuna Rao, Schwabe, Tina, Ehrlich, Gunter, Kusch, Jana, Benndorf, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122924/
https://www.ncbi.nlm.nih.gov/pubmed/29959170
http://dx.doi.org/10.1085/jgp.201711935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122924/
https://www.ncbi.nlm.nih.gov/pubmed/29959170
http://dx.doi.org/10.1085/jgp.201711935

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