Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

Pdgfra-expressing (Pdgfra+) cells have been implicated as progenitors in many mesenchymal tissues. To determine lineage potential, we generated Pdgfra(rtTA) knockin mice using CRISPR/Cas9. During lung maturation, counter to a prior study reporting that Pdgfra+ cells give rise equally to myofibroblas...

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Detalles Bibliográficos
Autores principales: Li, Rongbo, Bernau, Ksenija, Sandbo, Nathan, Gu, Jing, Preissl, Sebastian, Sun, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122952/
https://www.ncbi.nlm.nih.gov/pubmed/30178747
http://dx.doi.org/10.7554/eLife.36865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122952/
https://www.ncbi.nlm.nih.gov/pubmed/30178747
http://dx.doi.org/10.7554/eLife.36865

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