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Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis

In cytokinesis with chromatin bridges, cells delay abscission and retain actin patches at the intercellular canal to prevent chromosome breakage. In this study, we show that inhibition of Src, a protein-tyrosine kinase that regulates actin dynamics, or Chk1 kinase correlates with chromatin breakage...

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Detalles Bibliográficos
Autores principales: Dandoulaki, Maria, Petsalaki, Eleni, Sumpton, David, Zanivan, Sara, Zachos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122982/
https://www.ncbi.nlm.nih.gov/pubmed/29954829
http://dx.doi.org/10.1083/jcb.201802102