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Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis
In cytokinesis with chromatin bridges, cells delay abscission and retain actin patches at the intercellular canal to prevent chromosome breakage. In this study, we show that inhibition of Src, a protein-tyrosine kinase that regulates actin dynamics, or Chk1 kinase correlates with chromatin breakage...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122982/ https://www.ncbi.nlm.nih.gov/pubmed/29954829 http://dx.doi.org/10.1083/jcb.201802102 |