Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes

Neurons are large and long lived, creating high needs for regulating protein turnover. Disturbances in proteostasis lead to aggregates and cellular stress. We characterized the behavior of the short-lived dendritic membrane proteins Nsg1 and Nsg2 to determine whether these proteins are degraded loca...

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Detalles Bibliográficos
Autores principales: Yap, Chan Choo, Digilio, Laura, McMahon, Lloyd P., Garcia, A. Denise R., Winckler, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122995/
https://www.ncbi.nlm.nih.gov/pubmed/29907658
http://dx.doi.org/10.1083/jcb.201711039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122995/
https://www.ncbi.nlm.nih.gov/pubmed/29907658
http://dx.doi.org/10.1083/jcb.201711039

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