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Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high‐fat diet

AIMS/INTRODUCTION: Complete mechanisms of renoprotective effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors have not been elucidated yet. Mitochondrial biogenesis is regulated by membrane GTPases, such as optic atrophy factor 1 and mitofusion 2. Here, we investigated whether SGLT2 inhibiti...

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Detalles Bibliográficos
Autores principales: Takagi, Susumu, Li, Jinpeng, Takagaki, Yuta, Kitada, Munehiro, Nitta, Kyoko, Takasu, Toshiyuki, Kanasaki, Keizo, Koya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123054/
https://www.ncbi.nlm.nih.gov/pubmed/29352520
http://dx.doi.org/10.1111/jdi.12802