Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

Expression of the Vglut2/Slc17a6 gene encoding the Vesicular glutamate transporter 2 (VGLUT2) in midbrain dopamine (DA) neurons enables these neurons to co-release glutamate in the nucleus accumbens (NAc), a feature of putative importance to drug addiction. For example, it has been shown that condit...

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Detalles Bibliográficos
Autores principales: Papathanou, Maria, Creed, Meaghan, Dorst, Matthijs C., Bimpisidis, Zisis, Dumas, Sylvie, Pettersson, Hanna, Bellone, Camilla, Silberberg, Gilad, Lüscher, Christian, Wallén-Mackenzie, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123381/
https://www.ncbi.nlm.nih.gov/pubmed/30210305
http://dx.doi.org/10.3389/fncir.2018.00064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123381/
https://www.ncbi.nlm.nih.gov/pubmed/30210305
http://dx.doi.org/10.3389/fncir.2018.00064

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