FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway

Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking advantage of the metabolic flexibility of TNBC MDA-MB-231 cells to generate subpopulations with glycol...

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Detalles Bibliográficos
Autores principales: Urra, Félix A., Muñoz, Felipe, Córdova-Delgado, Miguel, Ramírez, María Paz, Peña-Ahumada, Bárbara, Rios, Melany, Cruz, Pablo, Ahumada-Castro, Ulises, Bustos, Galdo, Silva-Pavez, Eduardo, Pulgar, Rodrigo, Morales, Danna, Varela, Diego, Millas-Vargas, Juan Pablo, Retamal, Evelyn, Ramírez-Rodríguez, Oney, Pessoa-Mahana, Hernán, Pavani, Mario, Ferreira, Jorge, Cárdenas, César, Araya-Maturana, Ramiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123471/
https://www.ncbi.nlm.nih.gov/pubmed/30181620
http://dx.doi.org/10.1038/s41598-018-31367-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123471/
https://www.ncbi.nlm.nih.gov/pubmed/30181620
http://dx.doi.org/10.1038/s41598-018-31367-9

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