Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection

Enhanced telomere maintenance is evident in malignant cancers. While telomeres are thought to be inherently heterochromatic, detailed mechanisms of how epigenetic modifications impact telomere protection and structures are largely unknown in human cancers. Here we develop a molecular tethering appro...

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Detalles Bibliográficos
Autores principales: Chow, Tracy T., Shi, Xiaoyu, Wei, Jen-Hsuan, Guan, Juan, Stadler, Guido, Huang, Bo, Blackburn, Elizabeth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123478/
https://www.ncbi.nlm.nih.gov/pubmed/30181605
http://dx.doi.org/10.1038/s41467-018-05840-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123478/
https://www.ncbi.nlm.nih.gov/pubmed/30181605
http://dx.doi.org/10.1038/s41467-018-05840-y

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