Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell RNA-sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Here, we show that intercellular heterogeneity of g...

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Detalles Bibliográficos
Autores principales: Karaayvaz, Mihriban, Cristea, Simona, Gillespie, Shawn M., Patel, Anoop P., Mylvaganam, Ravindra, Luo, Christina C., Specht, Michelle C., Bernstein, Bradley E., Michor, Franziska, Ellisen, Leif W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123496/
https://www.ncbi.nlm.nih.gov/pubmed/30181541
http://dx.doi.org/10.1038/s41467-018-06052-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123496/
https://www.ncbi.nlm.nih.gov/pubmed/30181541
http://dx.doi.org/10.1038/s41467-018-06052-0

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