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The Telomerase Complex Directly Controls Hematopoietic Stem Cell Differentiation and Senescence in an Induced Pluripotent Stem Cell Model of Telomeropathy
Telomeropathies are rare disorders associated with impaired telomere length control mechanisms that frequently result from genetic mutations in the telomerase complex. Dyskeratosis congenita is a congenital progressive telomeropathy in which mutation in the telomerase RNA component (TERC) impairs te...
Autores principales: | Jose, Shyam Sushama, Tidu, Federico, Burilova, Petra, Kepak, Tomas, Bendickova, Kamila, Fric, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123533/ https://www.ncbi.nlm.nih.gov/pubmed/30210531 http://dx.doi.org/10.3389/fgene.2018.00345 |
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