An Effective Concentration of 5-Aza-CdR to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line through Reactivating RASSF1A and Up-Regulation of Bax Genes

BACKGROUND: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a DNA methyl-transferase inhibitor. The present...

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Detalles Bibliográficos
Autores principales: Nikbakht Dastjerdi, Mehdi, Azarnezhad, Asaad, Hashemibeni, Batool, Salehi, Mansour, Kazemi, Mohammad, Babazadeh, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Journal of Medical Sciences 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123548/
https://www.ncbi.nlm.nih.gov/pubmed/30214106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123548/
https://www.ncbi.nlm.nih.gov/pubmed/30214106

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