PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma

Hepatoblastoma (HBL) is a pediatric liver cancer that affects children under the age of three. Reduction of tumor suppressor proteins (TSPs) is commonly seen in liver cancer. However, in our studies we find that aggressive, chemo-resistant HBLs exhibit an elevation of TSPs. HBL patients with a class...

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Detalles Bibliográficos
Autores principales: Valanejad, Leila, Cast, Ashley, Wright, Mary, Bissig, Karl-Dimiter, Karns, Rebekah, Weirauch, Matthew T., Timchenko, Nikolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123626/
https://www.ncbi.nlm.nih.gov/pubmed/30271949
http://dx.doi.org/10.1038/s42003-018-0077-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123626/
https://www.ncbi.nlm.nih.gov/pubmed/30271949
http://dx.doi.org/10.1038/s42003-018-0077-8

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