Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Akt is a pro‐survival kinase frequently activated in human cancers and is associated with more aggressive tumors that resist therapy. Here, we connect Akt pathway activation to reduced sensitivity to chemotherapy via Akt phosphorylation of Bax at residue S184, one of the pro‐apoptotic Bcl‐2 family p...

Descripción completa

Detalles Bibliográficos
Autores principales: Kale, Justin, Kutuk, Ozgur, Brito, Glauber Costa, Andrews, Tallulah S, Leber, Brian, Letai, Anthony, Andrews, David W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123645/
https://www.ncbi.nlm.nih.gov/pubmed/29987135
http://dx.doi.org/10.15252/embr.201745235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123645/
https://www.ncbi.nlm.nih.gov/pubmed/29987135
http://dx.doi.org/10.15252/embr.201745235

Ejemplares similares