Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

Developmental dysplasia of the hip (DDH) is the most common skeletal developmental disease. However, its genetic architecture is poorly understood. We conduct the largest DDH genome-wide association study to date and replicate our findings in independent cohorts. We find the heritable component of D...

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Detalles Bibliográficos
Autores principales: Hatzikotoulas, Konstantinos, Roposch, Andreas, Shah, Karan M., Clark, Matthew J., Bratherton, Selina, Limbani, Vasanti, Steinberg, Julia, Zengini, Eleni, Warsame, Kaltuun, Ratnayake, Madhushika, Tselepi, Maria, Schwartzentruber, Jeremy, Loughlin, John, Eastwood, Deborah M., Zeggini, Eleftheria, Wilkinson, J. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123669/
https://www.ncbi.nlm.nih.gov/pubmed/30273415
http://dx.doi.org/10.1038/s42003-018-0052-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123669/
https://www.ncbi.nlm.nih.gov/pubmed/30273415
http://dx.doi.org/10.1038/s42003-018-0052-4

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