A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca(2+) sensitivity

Ryanodine receptors (RyRs) are Ca(2+) release channels in the sarcoplasmic reticulum of skeletal and cardiac muscles and are essential for muscle contraction. Mutations in genes encoding RyRs cause various muscle and arrhythmogenic heart diseases. Although RyR channels are activated by Ca(2+), the a...

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Detalles Bibliográficos
Autores principales: Murayama, Takashi, Ogawa, Haruo, Kurebayashi, Nagomi, Ohno, Seiko, Horie, Minoru, Sakurai, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123685/
https://www.ncbi.nlm.nih.gov/pubmed/30271978
http://dx.doi.org/10.1038/s42003-018-0103-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123685/
https://www.ncbi.nlm.nih.gov/pubmed/30271978
http://dx.doi.org/10.1038/s42003-018-0103-x

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